Studies Show Possible Link Between Esophageal Cancer and Fosamax

In September 2010, a study published in the British Medical Journal showed that there is a possible link between long-term use of bisphosphonates, such as Fosamax, and cancer of the esophagus. The study used an analysis of data from a nationwide medical practice research regfosamax lawsuitistry in the United Kingdom and followed about 90,000 patients for eight years. The study shows, like osteonecrosis of the jaw, that esophageal cancer risk is growing as the number of Fosamax users grows as well.

In people aged 60 to 70 who had ten or more prescriptions for oral osteoporosis drugs for about five years, the study found the risk for developing esophageal cancer risk was on the average 2 in every 1,000 cases. Normally, the risk of developing cancer of the esophagus, or throat, in people aged 60 to 70 is 1 in every 1,000 cases.

Also in a letter sent to the editor of the New England Journal of Medicine from a member of the United States Food and Drug Administration (FDA), reported that from October 1995 to May 2008 the FDA received reports of 23 patients who were diagnosed with esophageal cancer while taking the oral bisphosphonate medication, alendronate. The letter also stated that in Europe and Japan, there had been up to ten cases of cancer of the esophagus which could possibly be linked to bisphosphonate use. However, the author goes on in the letter that further studies are required to establish whether a clear link between the two can be established.

However, the author does also state that the major limitation of this report to the editor is the fact that this was not a prospective randomized clinical trial. Therefore at this time it is not possible to state that bisphosphonates, such as Fosamax, can actually cause esophageal cancer.  It could mean that it is entirely possible that the patients who developed cancer had pre-existing conditions that put them at risk for this type of cancer unrelated to the use of bisphosphonate medications.

The FDA did however issue this warning to doctors who would prescribe Fosamax and other bisphosphonates to patients: “patients should be instructed to carefully follow the directions for use of the drugs. Oral bisphosphonates — with the exception of risedronate delayed-release, — should be taken with a full glass of plain water just after awakening in the morning. Patients should not lie down or eat or drink anything for at least 30-60 minutes after taking any oral bisphosphonate.”

Further studies are still needed to know if osteoporosis drugs such as Fosamax can actually cause esophageal cancer. If these studies can prove that there is an actual link between Fosamax use and esophageal cancer, the number of Fosamax lawsuits that will be filed may raise in number. If you feel that you have been injured by the use of Fosamax in anyway, consult with a doctor as soon as possible.



Diagnosing Osteoporosis

Fosamax Side EffectsOver 10 million Americans are suffering from osteoporosis and 34 million more are at risk. The ultimate result of this major health problem could be several types of fracture. Hence, it is important that therapies are developed for this kind of bone disease. Fosamax is one of the drugs most often prescribed for this condition. The reports that this drug causes adverse effects became so depressing for some that they stop using it. This move is actually a good thing as discontinuing Fosamax use reduces second femur break risks.


Osteoporosis is a disease characterized by diminished bone mineral density (BMD). Many examinations are capable of getting concrete information of the health of your bones. Prior to any diagnostic exams done, your doctor may ask the following information to determine your risk of having the disease.


  • Any fractures you have incurred
  • Race, family history of osteoporosis
  • Medications taken
  • General intake of calcium and vitamin D
  • Lifestyle, activities and exercise pattern
  • Menstrual history for women


If your doctor believes you have osteoporosis, he/she may let you do any of these procedures.


X-rays. When one experiences low back pain and/or decrease in height resulting from stooped posture, an X-ray may be done to determine whether you have a fracture or if there is bone loss. However, x-ray may not be enough as it can only detect bone loss if more than 30% has been depleted and osteoporosis may be missed.


BMD tests. BMD test is the most accurate way to assess the health status of your bone. Among the most widely recognized BMD test is dual-energy x-ray absorptiometry scan or DEXA scan. This trouble-free procedure usually lasts around 10 minutes and can detect bone density and fracture risk with the use of limited radiation exposure.


CT Scan. During infrequent cases, quantitative computed tomography (QCT) may be done to confirm loss of BMD. This particular type of CT scan is used mainly to assess disease conditions that may be defined by unusual BMD as well as to monitor response to therapy for these conditions.


Whatever diagnostics you need to undergo, it is important that osteoporosis be detected as early as possible to start necessary intervention. However, being cautious is also necessary as osteoporosis preventions like the drug Fosamax have been reported to cause adverse effects like femur fractures and osteonecrosis of the jaw (ONJ). In fact, the makers of this drug are currently facing lawsuits due to these numerous Fosamax side effects.



Fosamax Overdose: Symptoms And Treatment

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Fosamax, otherwise known by its generic form alendronate sodium, is a biphosphonate that strengthens the bones in patients with osteoporosis. Yet this drug is now sharing the limelight with Fosamax Plus D because of increasing reports of atypical type of femoral fracture from its long-term customers. The verdict of the arbitrator is almost at arm’s length  now that there has been a development in the New Jersey Fosamax Femur Fracture Lawsuits.

Fosamax is a drug given to patients with the intentions of bringing out its beneficial effects. This drug, just like any other, carries along potentially serious side effects particularly in the gastrointestinal tract. As it goes with any medication as well, excessive intake of the drug may lead to Fosamax overdose.

The effects of a Fosamax overdose may vary according to a number of factors which includes the amount of Fosamax taken and whether it was taken with other medications or substances. Furthermore, the most common manifestations of the Fosamax overdose are as follows:

  • Heartburn or indigestion
  • Calcium and/or phosphate levels in the blood are below normal range (hypocalcemia and hypophosphatemia respectively)
  • Ulcerations in the esophagus (tube connecting the mouth to the stomach), stomach or intestine

The treatment to manage Fosamax overdose will also vary, however, induced vomiting should not be done because the drug itself can be irritating to the digestive tract especially the esophagus. Nevertheless, you can stop the drug from entering the bloodstream by taking in milk or antacids (drugs that may counteract with stomach’s acidity.)

Treatment may also include supportive measures, which consists of correcting the symptoms due to the excessive amounts of drug taken.These supportive treatment options may include:

  • Careful monitoring of the heart rate, blood pressure and breathing (respiratory rate)
  • Starting Intravenous (IV) line for fluid replacement
  • Intravenous therapy of calcium to improve calcium levels in the blood
  • Other treatments depending on the symptoms manifested

You need to urgently seek medical assistance if you have overdosed yourself with Fosamax.

It is important that you strictly adhere to your doctor’s order when taking your Fosamax therapy. If you missed a daily dose, you need to skip that dose just wait for your next schedule the next morning. If you forget to take your medication for a weekly basis, you need to take to that dose the next morning after you remembered that dose and just go back to your usual schedule on the next dose. Never take two doses a day.

Never take any Fosamax complaints or side effects for granted especially overdoses. Moreover, a Fosamax Fracture Lawsuit will never be enough to compensate any loss in your health because of the drug.

Osteoporosis Treatment Fosamax and It’s Side-effects

Every man grows old, and as he ages, so does his body. We witness the majestic aging process through our aging elders, and to ourselves we even find these transitions too. There are many things that goes along with the aging process, one of this is osteoporosis commonly seen in postmenopausal women but can affect men too. Nevertheless, it is good to know there are special treatments for those who are plagued with osteoporosis, such as lifestyle changes comprising changes in one’s diet, exercise and safety, along with pharmaceutical drugs such as the famous treatment for osteoporosis, the biphosphonate Alendronate Sodium (also comes in the popular brand name Fosamax). Recent reports linked the drug to harmful side-effects such as atypical, low-energy femur fracture and osteonecrosis of the jaw disease.

Healthcare professionals often prescribe the biphosphonate drug Alendronate Sodium (brand name Fosamax) which was manufactured by the pharmaceutical company Merck. The drug is used by women with high risk in fracture due to osteoporosis and some other dilapidated condition affecting the bones strength. The has proven to work in bone strengthening and fracture prevention as attested by Fosamax users taking it for four years, but those who were using the drug over four years reported otherwise. Reports came that some had unusual femur fracture during mundane activities such as walking, others had gruesome osteonecrosis of the jaw or “dead jaw” disease which affects the jaw bones, and esophageal ulceration which was believed to progress into esophageal cancer.

The side-effects of Fosamax frequently observed are some GI problems in the form of flatulence, constipation, diarrhea, and vomiting, few cases of skin problems and eye inflammation problems, while the least common side-effects are neuropsychological in nature which are auditory hallucinations and visual impairments.

The dire side-effects an osteoporosis patient may endure is staggering. If you experienced any of the given Fosamax grave side-effects, or if any of your loved one suffered from any of these, know that you have the right to demand just compensation for the damages endured. You can talk to a Fosamax fracture lawyer who is adept and knowledgeable about the legal matters of Fosamax lawsuits and file your Fosamax Femur Fracture Lawsuit. You can consult one right now, for free. For more information, check out Fosamax lawsuit sites.

The General and More Severe Side Effects of Fosamax

While the amount of Fosamax Femur Lawsuits being filed are starting to grow in number, many still tend to only focus at the major side effects of Fosamax, such as osteonecrosis of the Jaw. But Fosamax, like any other drug, does have it’s own general side effects.

These are the general side effects that Fosamax has been known to cause: bone, muscle, or joint pain; constipation; diarrhea; dizziness; feeling bloated or full; flu-like symptoms at the start of treatment; gas; headache; mild stomach pain; nausea; taste changes; vomiting.

There are also many severe side effects of Fosamax you should know about. If you begin to show any of these SEVERE side effects of Fosamax, it is strong advised that you seek medical attention as soon as possible:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; chest pain; coughing or vomiting blood; difficult or painful swallowing; mouth sores; new, worsening, or severe heartburn; red, swollen, blistered, or peeling skin; severe bone, muscle, or joint pain (especially in the hip or thigh); severe or persistent sore throat or stomach pain; swelling of the hands, legs, or joints; swelling or pain in the jaw.

The side effects stated above are just some of the side effects Fosamax can cause. As with any drug, these side effects would change from person to person as Fosamax would affect each person differently. There are many factors to take into consideration when thinking why some do not show side effects while others do, age, gender, weight, and height all can affect how Fosamax can a person. If you have started to show any of the side effects mentioned, it is advisable to consult with your physician right away.

If you believe that you have been injured by the consumption of Fosamax, or know someone who has begun to show side effects, then you should know your rights. Please remember that you should always visit your doctor the moment any side effects of Fosamax begin to show. You can always try and contact as Fosamax Femur Lawyer, as many will give you a free consultation and will not charge you unless you win your case in court.